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Kolja Henckel

Mediplex - combining expression datasets of Medicago truncatula


Creating a software infrastructure to mine GeneChip expression data and to combine different Medicago truncatula expression profiling datasets
2010. 160 S. 220 mm
Verlag/Jahr: SÜDWESTDEUTSCHER VERLAG FÜR HOCHSCHULSCHRIFTEN 2010
ISBN: 3-8381-1881-2 (3838118812)
Neue ISBN: 978-3-8381-1881-9 (9783838118819)

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Medicago truncatula is a model plant for studying legume biology. The ability to interact with beneficial microbial organisms leading to the formation of nitrogen fixing root nodules and to phosphate-acquiring arbuscular mycorriza (AM) is one of the main distinctive features of this family of plants. In this book, the implementation of an analysis pipleline for the evaluation of Affymetrix GeneChips is pointed out. The microarray anbalysis software EMMA2 is extended to load, store, and anbalyze GeneChip expression datasets. A data warehouse storing sequences, annotations, and experimental expression datasets is created and can be used at . Finally, a software to combine EST expression datasets and microarray datasets is created, such that differentially expressed genes can be searched and analyzed.
Born in 1979 in West-Berlin, Kolja Henckel grew up in Lüdenscheidin the Sauerland. After finishing his studies in computer sciencein the natural science in Bielefeld, he made his PhD at thetechnical faculty at Bielefeld University. Today he lives withhis wife and his two children in Bielefeld.