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Alexandros Poulopoulos

Synaptogenesis in the Mammalian Central Inhibitory Synapse


Mechanisms of Neuroligin Function in Inhibitory Postsynaptic Differentiation
2010. 172 S.
Verlag/Jahr: SÜDWESTDEUTSCHER VERLAG FÜR HOCHSCHULSCHRIFTEN 2010
ISBN: 3-8381-2266-6 (3838122666)
Neue ISBN: 978-3-8381-2266-3 (9783838122663)

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The establishment of accurate synaptic transmission underlies neural network processing and nervous system function. The organized deployment of specialized synaptic machinery is a key cellular process that shapes the synapse and its transmission properties, yet the molecular mechanisms involved in assembling the synaptic apparatus are largely unknown. This work has focused on the role of Neuroligins, a family of postsynaptic adhesion molecules, in mediating differentiation of inhibitory, GABAergic and glycinergic, postsynapses.
The author was born in Athens, Greece. He received his primary education in Ithaca, NY and Grenoble, France where he lived till the age of thirteen. Back in Athens, he graduated from the EP Lyceum of Alimos and studied Biology in the University of Athens. In 2003 he moved to Göttingen, Germany to study Neuroscience, receiving a PhD in 2008.