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The Drug Metabolism and Pharmacokinetics, Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.

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Pharmacokinetics.- Drug Metabolizing Enzymes.- Biotransformation.- Transporters.- Drug-Drug Interaction.- Bioactivation and Toxicophores.- Use of Protein, Tissue and Microsomal Binding.- Prediction of Human Pharmacokinetics.- PK/PD Modeling.- Bioanalyticals.- Physicochemical Properties and Drug-like Properties.- In Silico Tools.- Data Mining.- Chemical Nomenclature.- References

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From the reviews:

"The authors have to be complimented with this comprehensive book of reference on various important topics in the field of pharmacokinetics and drug metabolism. It contains a large collection of figures and tables providing relevant and well-organized information. ... In conclusion, this is a valuable reference for workers in the field of pharmacokinetics and drug metabolism, providing a storehouse of information in a comprehensive book." (Johannes H. Proost, International Journal of Clinical Pharmacology and Therapeutics, Vol. 50 (6), June, 2012)

"The authors intend the book to inform important decisions in a timely fashion ´for synthesis of superior compounds that have the potential for being a safe and effective drug´. The summary format was designed to be clear, concise and self-explanatory, so it could be used on a daily basis to inform those design decisions. It achieves this goal. It is intended for all drug-discovery scientists, and researchers in all disciplines will certainly find it useful. ... In summary, this is a valuable little book." (Andy Davis, ChemMedChem, Vol. 7, 2012)
"This guide can be used on a day-to-day basis as a useful reference for almost anyone, including students first learning these concepts, as well as scientists in the pharmaceutical industry hoping to apply these principles in their research. ... This is a nicely organized quick reference on basic concepts in pharmacokinetics and drug metabolism. It will be a useful addition to the libraries of a variety of readers, from students in the pharmaceutical sciences to accomplished researchers in drug development." (Melissa M. Ranieri, Doody´s Book Reviews, December, 2011)

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