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This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders.

Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics
Identifies key concepts, methods, and findings
Includes coverage of multiple disorders from autism to schizophrenia
Reviews specific genes associated with disorders
Discusses the genetic architecture of these syndromes
Explains how recent findings are influencing the understanding of biology
Clarifies the promise of these findings for future treatment

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Section 1 The Genome Tools and Methods

1. The Newly Emerging View of the Genome

Stephan Sanders

2. Genetic Epidmeiology

Kathleen Ries Merikangas

3. Common Variation

Mark Daly

4. Rare/Structural Variation

Daniel Barrera and Jonathan Sebat

5. Epigenetics and Epigenomics

Eric J. Nestler and John Greally

6. Bioinformatics

Shaun Purcell

7. Imaging Genomics

Paul Matthew Thompson

8. Stem Cell Technology and Genomics

Alysson Renato Muotri

9. Association Strategies

Benjamin M. Neale

10. The promise of Systems Biology

Eric Schadt

11. Gene networks in neuropsychiatric disease

Daniel Geschwind

12. Mosaicism

Christopher A. Walsh and Saumya Shekhar Jamuar

Section 2 A new neuroanatomy

13. Mapping the Molecular Landscape of the Human Brain

Nenad Sestan

14. Studying Circuits

Stephan Lammel and Robert Malenka

15. Electrophysiological Measurement of Circuits

Srikantan S. Nagarajan

16. Imaging the Circuitry of the Human Brain

Michael Greicius

17. Neuroimaging Advances in Alzheimer´s Disease

Daniel R. Schonhaut and Gil Rabinovici

18. Progressive Supranuclear Palsy and Related Parkinsonian Disorders

Jesse A. Brown and William Seeley

19. The Anatomy of Basal Ganglia Circuitry of Behavior

Nicholas Au Yong, Adrienne M. Keener, Yvette Bordelon, Carlos Portera-Cailliau and Nader Pouratian

20. Brainstem Circuitry of Behavior

Helmut Heisen

21. Apathy - Basal Ganglia, Frontal Circuits

Mario F. Mendez

22. Emotion Circuitry

Robert Wayne Levenson

23. Delusions

Georges Naasan

24. Hallucinations

Dennis Velakoulis

Section 3 Clinical Phenomenology

25. Intro: Risk Overlap Among Disorders

Patrick Sullivan

26. The conundrum of Clinical Characterization RDOC/ICD-10/DSM

Bruce N. Cuthbert

27. Schizophrenia

Aiden Corvin

28. Psychosis

Raquel E. Gur and Ruben Gur

29. ASD

Rebecca Ann Muhle, Stephan Sanders, Hannah Reed and Matthew William State

30. Bipolar Disorder

Nelson B. Freimer, Carrie E. Bearden and Peter Zandi

31. MDD

David C. Glahn

32. Speech and Language Disorders

Marilu Gorno-Tempini

33. Molecular Pathways Leading to the Clinical Phenomenology of Frontotemporal Dementia

Suzee Eurie Lee and Jennifer S. Yokoyama

34. Alzheimer´s

Rudy Tanzi

35. PTSD

Kerry Ressler

36. Neurodevelopmental syndromes

Elliott Sherr

37. Epilepsies

Ryan S. Dhindsa, Daniel Lowenstein and David Goldstein

38. Substance Abuse

Nii Addy

39. Neuroimmunology

Emmanuel Mignot

40. Brain Tumors

Vanessa Clark and Murat Günel

41. White Matter Disorders

Michael David Geschwind and Brianne Magouirk Bettcher

42. ALS

Elena Ratti and James Berry

43. Eating Disorders

Cynthia M. Bulik and Garret Stuber

Section 4 Clinical Translation and Drug Development

44. Pharmacogenomics

Roy H. Perlis

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