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Dieses verständlich geschriebene Lehrbuch vermittelt alles Wissenswerte rund um die molekulare Onkologie. Vor allem die bei vielen Krebsarten wichtigen Signalwege werden detailliert dargestellt. Eine Vielzahl von Lehrvideos machen das Thema erfahrbar.

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General Aspects of Signal Transduction and Cancer Therapy
Tumor Cell Heterogeneity and Resistance to Targeted Therapy
Cell Cycle of Tumor Cells
Cell Aging and Cell Death
Growth Factors and Receptor Tyrosine Kinases
The Philadelphia Chromosome and BCR-ABL1
MAPK Signaling
PI3K-AKT-mTOR Signaling
Hypoxia-Inducible Factor (HIF)
NF-kappaB Pathways
Wnt Signaling
Notch Signaling
Hedgehog Signaling
TGFbeta Signaling

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The role of intracellular signaling pathways in cancer development (introduction)
The cellular view
The cell cycle
Apoptosis
Communication of tumor cells with the microenvironment
Vicious cycle in the generation of osteoclastic bone metastases in mammay cancer
The molecular view
Oncogenic receptor tyrosine kinase activation
Protein kinase C
The MAP Kinase (MAPK) signaling pathway
Molecular action of TP53 in carcinogenesis
The Wnt pathway in a normal and in a tumor cell
Effects of proteinases with metalloproteinase domains (MMPs, ADAMs) on tumor progression
BCR-ABL and the philadelphia chromosome
Oxygen sensing by Hypoxia inducible factor (HIF)
SRC kinThe role of intracellular signaling pathways in cancer development (introduction)
The cellular view
The cell cycle
Apoptosis
Communication of tumor cells with the microenvironment
Vicious cycle in the generation of osteoclastic bone metastases in mammay cancer
The molecular view
Oncogenic receptor tyrosine kinase activation
Protein kinase C
The MAP Kinase (MAPK) signaling pathway
Molecular action of TP53 in carcinogenesis
The Wnt pathway in a normal and in a tumor cell
Effects of proteinases with metalloproteinase domains (MMPs, ADAMs) on tumor progression
BCR-ABL and the philadelphia chromosome
Oxygen sensing by Hypoxia inducible factor (HIF)
SRC kinase and its substrates
Dysregulated signaling proteins as starting points for cancer therapy
- BCR-ABL
- Raf kinase
- Her2
- EGF receptor
ase and its substrates
Dysregulated signaling proteins as starting points for cancer therapy
- BCR-ABL
- Raf kinase
- Her2
- EGF receptor

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