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In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries.
Combining theory and practice, the authors explain such leading-edge technologies as single-use bioreactors, bioreactor simulators, and soft sensor monitoring, and discuss novel applications, such as stem cell production, process development, and multi-product reactors, using case studies from academia as well as from industry. A final section addresses the latest trends, including culture media design and systems biotechnology, which are expected to have an increasing impact on bioreactor design.
With its focus on cutting-edge technologies and discussions of future developments, this handbook will remain an invaluable reference for many years to come.

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New bioreactor design challenges: An Overview
Bioreactors for expansion of induced pluripotent stem cells and their differentiation to cardiac cells
Scale up of stem cell manufacture for cell therapy needs
Culturing entrapped hESC in continuous stirred reactors
Artificial liver bioreactor design
Design of microbioreactor system for process development, Multivariate modeling for bioreactor monitoring and control
Rational integration of bioreactors with primary recovery
Virtual operator training simulators for bioreactors
Soft sensor monitoring and control of bioreactors
Coping with physiological stress in recombinant protein production by bioreactor design
The design bottlenecks with single use bioreactors
The Bioreactor-on a-Chip
Multibioreactors and Design-of-Experiments
Culture media design
Systems biotechnology

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Carl-Fredrik Mandenius is professor of Engineering Biology at Linköping University (Sweden) since 1999 and head of the Division of Biotechnology. He holds a master and PhD degree in Engineering from Lund University. His main research interests are bioprocess engineering, biosensor technology and biotechnology design.

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