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Cell migration in confined environments is a burning topic, since it is one of the main biological processes ruling embryogenesis, cancer metastasis or an organism immune system. Based on a previously developed cell confined migration model and the observation of micro-channels experiments, this thesis focuses of two main aspects. First, the evidence that the nucleus was capable of breaking its lamina to pass through narrow sub-nuclear constrictions led us to reconsider the way it was defined: different rheological models for the lamina and the nucleoplasm are thus used. Secondly, the confined migration model relied on an adhesion-based migration mode, while all the recent interest in cell migration through confined environments featured a compression-based migration mode in which the cell would not need to form any focal adhesions with the substrate. Hence, a new migration model is developed to describe this adhesion-free mode that mostly occurs during three-dimensional confined migration and is referred to as ´chimneying´, since it mimics the behavior of a rock climber in a chimney.

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French engineer from CentraleSupelec (formerly Ecole Centrale Paris), Solenne Deveraux also graduated from the Biomedical Engineering master of the TU Wien in June 2015. She then started a PhD at CentraleSupelec, working on numerical models accounting for the role of the nucleus during confined cell migration.

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