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Adaptive randomization designs have become an alternative of pure randomization in clinical trials for many decades. The main purpose of this adaptations is to reduce the imbalance between patients (Experimental Units) who are assigned to different treatments. To achieve this aim, several approaches are addressed by researchers in biostatistics field. In this book, adaptive design definitions, types and methods are covered. Covariate adaptive randomization approaches such as, Zelen´s, Pocock-Simon´s, Imbalance Minimization, critical percentage and others methods are discussed in details as well as a comparative experiment to examine the performance of adaptive methods against pure randomization in term of imbalance at different sample sizes. So, this book will be highly beneficial for the researchers in statistics, biostatistics, biopharmaceutical statistics and related fields.

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Dr. Montasir Ahmed Osman _ Assistant professor of Statistics, department of maths ,university of Kassala, Kassala, Sudan. He hold a PhD in biostatistics and authored many research papers in scientific journals and international conferences. He worked as a reviewer of international conferences.

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