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1) From discovery by Bergantin et al. (Cell Calcium, 2013) of involvement of interaction of intracellular signaling pathways mediated by Ca2+ and cAMP (Ca2+/cAMP interaction) in the paradoxical sympathetic hyperactivity produced by L-type CCB during antihypertensive therapy (phenomenon entitled as "calcium paradox"); 2) Physiological and pathological role of Ca2+/cAMP interaction on the secretory response of sympathetic neurons and adrenal chromaffin cells; 3) Potential pharmacological therapeutic translation to human health and disease of the "calcium paradox": hypertension, neurological/psychiatric disorders (Alzheimer s and Parkinson s diseases, and depression) and drug interaction in practical medicine.

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Dr. Bergantin received his academic education at EPM-UNIFESP (Brazil) and UAM (Spain): degree in biomedicine (2008), MSc (2010) and PhD (2014). His research work solved the enigma of the paradoxical effects produced by L-type Ca2+ channel blockers (ScienceDirect TOP 25 Hottest Articles - Biochemistry, Genetics and Molecular Biology - Cell Calcium).

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