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Late into the last quarter of the twentieth century, it has been witness an unprecedented crisis in the human race following the discovery of the seeming insurmountable viral load (HIV) compounded by its emerging allies of pathogenic infectivity, which often transmute to the deadly AIDS resulting to lethal outcome. On the other hand, face with the problem of outright eradication of the disease, research scientists have resorted to mathematical modeling for formulation of dynamic approaches of understanding the disease transmission, methodological application of therapies via optimization control theory. Addressing the persistent optimal control problem of de-mutation of dual HIV-pathogen infections via multiple chemotherapy treatment in the presence of delay intracellular and cell-mediated immune effectors response, the present work is a collections of series articulated scientific publications of the very author and other research thinkers. The volume of the present text is subdivided into six chapters, thought and designed to be used as a supplement or as a complete text-guide for students and researchers as well as those but not limited to medical, life and physical sciences.

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The author, a scientific researcher in the area of infectious diseases with well over 23 international research publications, is a citizen of Akpoha in Abi L.G.A, Cross River State, Nigerian; an academia - Cross River University of Technology, Calabar. He is a philosopher in computational Mathematics and Informatics, Kuban State University, Russia.

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