Tacrolimus ointment is licensed for the topical treatment of moderate to severe atopic dermatitis in patients who are not adequately responsive to or are intolerant of conventional therapies such as topical corticosteroids. There are many immune-mediated skin diseases that are commonly difficult to manage with conventional therapy and often no general and standardized treatment algorithms exist. This book from international experts summarizes the latest evidence of special treatment indications in which tacrolimus ointment has been investigated in clinical trials, accompanied by individual case reports from the own clinical practice.