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David Hollar

Epigenetics, the Environment, and Childrenīs Health Across Lifespans


Herausgegeben von Hollar, David
Softcover reprint of the original 1st ed. 2016. 2018. xxi, 386 S. 8 SW-Abb., 16 Farbabb., 12 Tabellen
Verlag/Jahr: SPRINGER, BERLIN; SPRINGER INTERNATIONAL PUBLISHING 2018
ISBN: 3-319-79770-0 (3319797700)
Neue ISBN: 978-3-319-79770-0 (9783319797700)

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This stimulating volume addresses vital questions about gene/environment interactions as they affect cell health from the prenatal period through later life. Beginning with a tour of epigenetic processes in the human body, the book assembles current theoretical and empirical developments across the discipline, among them transgenerational epigenetic inheritance, the effects of maternal nutrition on epigenetic change, and possible links between epigenetics and childhood obesity. Public health and policy aspects of the field are discussed in depth, with the understanding that much can be done to improve our epigenetic health as a species. And in this vein, contributors consider future possibilities, such as the reprogramming of genes to reverse cancer and other diseases.

Included in the coverage:

The role of environmental epigenetics in perinatal and neonatal development
The epigenetic biomarker GammaH2AX: from bench science to clinical trials
Whatīs the risk? Dental amalgam, mercury exposure, and human health risks throughout the lifespan
Post-traumatic stress disorder: neurological, genetic, and epigenetic bases
Childrenīs exposure to alcohol, tobacco, and drugs: long-term outcomes
Ethical implications of epigenetics
Epigenetics, the Environment, and Childrenīs Health Across Lifespans brings real-world knowledge and applications of this increasingly important field to public health practitioners, maternal and child health researchers, and environmental health experts.
Epigenetics and Development: A Natural Process.- Cause and Effect in Epigenetic Disease Epidemiology.- Epigenetics and Health.- Molecular Basis of Epigenetics.- Trans-generational Epigenetics.- Maternal Exposure to Pharmaceuticals.- Maternal Exposure to Poor Nutrition.- Maternal Exposure to Alcohol, Tobacco, and Drugs.- Maternal Exposure to Lead and Mercury.- Maternal Exposure to Stress.- Paternal Exposure to Environmental Mutagens and Stressors.- Protective Nutrition Before and During Pregnancy.- Protective Behaviors Before and During Pregnancy.- Impact of Dental Mercury on Lifespan Health.- Childrenīs Exposure to Stress.- Childrenīs Exposure to Lead and Mercury.- Childrenīs Exposure to Alcohol, Tobacco, and Drugs.- Childrenīs Exposure to Violence.- Childrenīs Exposure to Traumatic Events.- Childrenīs Exposure to Poor Nutrition.- Infection Impact on Child Development and Epigenetics.- HLA and Immune Response.- Allostatic Load.- Latent Periods and Cardiovascular/Cancer Risks.- Dynamics of Life Experiences on Polygenic Gene Regulation.- Food Chain Impact of Pesticides on Human Health.- Sun and Artificial Radiation Exposure on Skin Health.- Medical Imaging Radiation Risk on Health.- Naturopathic Approaches to Epigenetic Health.- Reprogramming Epigenetic Effects.- An Ecological Systems Approach to Epigenetic Health.- The Health Leaderīs Guide to Promoting Epigenetic Health.
"Gene/environment interaction are a young field of research, playing a great role on the intrauterine and postnatal development. The understanding of the significance of epigenetic mechanisms is clearly described in 16 chapters with a large list of references. For geneticists, neonatologists and pediatricians." (Pediatric Endocrinology Reviews (PER), Vol. 14 (2), December, 2016)

"The author describes the purpose as providing healthcare providers, policy makers, and healthcare consumers with a consultative resource to improve epigenetic health worldwide. ... It is directed at healthcare professionals as well as those interested in public health directives. ... Geneticists, as well as those involved in health surveillance such as cancer, may find this book very educational. ... It should raise awareness among the general public about epigenetics. There are very few books that deal with this subject." (Luis F. Escobar, Doodyīs Book Reviews, May, 2016)