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This essential
volume comprehensively discusses redox-active therapeutics, focusing
particularly on their molecular design, mechanistic, pharmacological and
medicinal aspects. The first section of the book describes the basic
aspects of the chemistry and biology of redox-active drugs and includes a brief
overview of the redox-based pathways involved in cancer and the medical aspects
of redox-active drugs, assuming little in the way of prior knowledge.
Subsequent sections and chapters describe more specialized aspects of central nervous system injuries, neurodegenerative
diseases, pain, radiation injury and radioprotection (such as of brain, lungs, head
and neck and erectile function) and neglected diseases (e.g., leishmaniasis).
It encompasses several major classes of redox-active experimental therapeutics, which
include porphyrins, salens, nitrones, and most notably metal-containing (e.g.,
Mn, Fe, Cu, Zn, Sb) drugs as either single compounds or formulations with
nanomaterials and quantum dots. Numerous illustrations, tables
and figures enhance and complement the text; extensive references to relevant
literature are also included.

Redox-Active Therapeutics is an invaluable addition to Springer´s Oxidative
Stress in Applied Basic Research and Clinical Practice series. It is essential reading for researchers, clinicians and graduate students
interested in understanding and exploring the Redoxome-the organism redox
network-as an emerging frontier in drug design, redox biology and medicine.

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