A multi-modal AVC system (AVC 2.0) is applied and implemented on a lightweight stress-ribbon bridge with inertial sensors and pneumatic muscle actuators to reduce the multi-modal spatial vibration.Lightweight footbridges are usually elegant and pleasing in terms of their structural design; however, they are prone to high-vibration sensitivity under pedestrian traffic. Multi-modal active vibration control (AVC) techniques with sensors and actuators could be potential alternatives to decrease multi-modal vibrations and guarantee the pedestrian comfort. The research object is the stress-ribbon footbridge in the lab at the Chair of Conceptual and Structural Design of Technische Universität Berlin. The extremely low bending stiffness as well as the extremely low structural damping lead to an unusually high vibration sensitivity not only in the vertical direction but also in the spatial dimension. Additionally, pedestrian-induced vibration on the lightweight footbridge demonstrates multi-modal time-varying characteristics in both time-frequency analysis (TFA) and experimental modal analysis. A multi-modal AVC system (AVC 2.0) is applied and implemented on the stress-ribbon bridge with inertial sensors and pneumatic muscle actuators (PMAs) to reduce the multi-modal vibration in vertical and torsional modes.