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The objective of evaluate growth, enzyme activity, metabolic responses, and hematological parameters in pacamÆ catfish (Lophiosilurus alexandri). Four diets with different levels of substitution of the cornmeal (CM) by guava meal (GV) 0, 33, 66, and 100% were tested and the feeding rate was 6% of the total body weight. A total of 160 experimental fish with an average initial weight of 16.29 g were distributed in 16 aquaria and fed for 45 days. Growth, metabolic, and hematological parameters, and digestive enzyme activity were evaluated at the end of the experiment. The level of substitution of 100% of the growth parameters were affected by the substitution of CM by GM. No effect was recorded in survival (P0.05). The values referring to the metabolic profile and hematological parameters variables were changed when CM was substituted by GM (P0.05). The digestive enzyme activities were influenced by the substitution of CM by GM (P0.05). The CM may be replaced by GM in up to 66% in diets for pacamÆ catfish without impairing their performance, metabolism, hematology, or digestive enzyme activity.

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1 PhD in Animal Science by the Federal University of Bahia. He is currently Associate Professor at the Federal University of the West of Bahia, Multidisciplinary Center Barra.2 PhD in Physiological Sciences, Federal University of SÆo Carlos. He is currently an Associate Professor at the Federal University of the SÆo Francisco Valley.

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