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The present work tackled the development and evaluation of inclusion complex of khellin (KH) and methyl-beta-cyclodextrin (MbetaCD). In addition, it tested its possible hypoglycemic and hypolipidemic effects. This study points for the first time that the complexation of Khellin with Methyl-betaCyclodextrin could notably improve the dissolution rate and hence the bioavailability of khellin. Moreover, this study demonstrated that this compound has a hypoglycemic and hypolipidemic effect. Thus, it can be a promising natural supportive treatment for type 2 diabetes mellitus (T2DM).

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Mona Mahmoud AbouSamraNational Research Center (NRC), El-Bohouth street, Dokki, Giza. Experience in the field of drug formulation using the Nanotechnology. Several publications in the field of pharmaceutical technology concerned with recent advances in drug delivery and nanotechnology.

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