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The book provides an essential reference on metastatic bone disease (MBD) for practicing orthopedists. It features rich and detailed images for diagnostic and referential purposes and includes the insights of leading practitioners and researchers.

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Providing an integrated approach to the diagnosis and management of patients with metastatic bone disease (MBD), this comprehensive text combines discussion of the pathobiology of the disease with the latest oncological and orthopedic treatment modalities. After opening with an examination of the epidemiology and impact of MBD, the biology of bone metastases are discussed, along with considerations of the tissue of origin. Evaluation, biopsy and medical therapy, including metabolic agents and bio targeting. The heart of the book presents oncological approaches (supportive, radiation and interventional) and principles of orthopedic surgical oncology, with subsequent chapters covering specific anatomy, from the pelvis to the lower extremity and the spine. Chapters on emerging surgical technology and future directions conclude the text and redefine an integrated approach to patient care. Taken together, Metastatic Bone Disease is an excellent resource for orthopedic surgeons and cancer specialists alike.

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R. Lor Randall, MD, FACS, The L.B. & Olive S. Young Endowed Chair for Cancer Research Director, Sarcoma Services & Medical Director, HCI Surgical Services Chief, SARC Lab & Fellowships Co-Leader, Sarcoma Disease Oriented Research Team, Professor of Orthopaedics, Primary Children´s Hospital & Huntsman Cancer Institute, The University of Utah Salt Lake City, UT.

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