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This book provides a current understanding of Continuous Renal Replacement Therapies (CRRT) techniques with a focus on drug dosing in critically ill children receiving CRRT. Strategies include the role of therapeutic drug monitoring, effect of CRRT on drug pharmacokinetics, variations in the drugs properties, newer kidney injury biomarkers and simple and easy methods for estimating drug clearance. The conclusion of this book features case reports focused on the patients´ symptoms and laboratory data as they present in clinical practice and the type of CRRT modality needed to provide quality, safety, and cost-effectiveness of patient care. Pediatric Continuous Renal Replacement Therapy will expand the clinical knowledge and experience of practicing nephrologists and other professionals involved in the care of children suffering from Acute Kidney Injury (AKI) to improve and sustain their quality of life.

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Acute kidney injury

CRRT as treatment

Water and solute movements: basic physiology

CRRT modalities

Hemodialysis (diffusive) versus hemofiltraion (Convective) CVVH

CRRT Principles

General consideration for CRRT

Specific consideration for pediatric CRRT

Vascular access and catheter size

Blood flow rate (BFR)

Ultrafiltation rates

Calculating the desired fluid removal rate

Replacement/dialysate solutions

Drug dosing in CRRT

Blood priming

Nutrition in CRRT

Monitoring during CRRT

Compliance of CRRT

Replacement/dialysate solution composition

Factors influencing the clearance of drug during CRRT

CRRT impact on pharmacokinetic parameters

Case Studies

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"The book is written for residents and practitioners in pediatric critical care and nephrology. ... It covers acute kidney injury, pharmacology of drugs in acute kidney injury, and continuous renal replacement therapy modalities." (Aftab Chishti, Doody´s Book Reviews, September, 2017)

"An updated practical guide for the treatment of acute kidney injury with didactic illustrations and tables. For pediatric nephrologists." (Zvi Laron, Pediatric Endocrinology Reviews, Vol. 13 (4), June, 2016)

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Farahnak Assadi, M.D.

Distinguished Professor, Emeritus

Department of Pediatrics

Rush University Medical College




Division of Nephrology

Rush Children´s Hospital

Chicago, Illinois

USA




Fatemeh Ghane Sharbaf, M.D.

Associate Professor

Department of Pediatrics

Section of Nephrology

Mashhad University of Medical Sciences

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