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This book introduces the latest advances relating to the pathophysiology, biophysics, monitoring and treatment of traumatic brain injury, hydrocephalus, and stroke presented at the 16th International Conference on Intracranial Pressure and Neuromonitoring (the "ICP Conference"), held in Cambridge, Massachusetts, in June 2016 in conjunction with the 6th Annual Meeting of the Cerebral Autoregulation Research Network. Additionally, the conference held special sessions on neurocritical care informatics and cerebrovascular autoregulation. The peer-reviewed papers included were written by leading experts in neurosurgery, neurointensive care, anesthesiology, physiology, clinical engineering, clinical informatics and mathematics who have made important contributions in this translational area of research, and their focus ranges from the latest research findings and developments to clinical trials and experimental studies. The book continues the proud tradition of publishing key work from the ICP Conferences and is a must-read for anyone wishing to stay abreast of recent advances in the field.

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"This book will be of most interest to bioengineers interested in cerebrovascular autoregulation, CSF biophysics, and physiological monitoring of the brain. It also will be of some interest to academic neurotraumatologists and neurointensivists. ... The editor has provided an index of key words at the end of the book, referred to as a ´subject index´ that will efficiently take the reader directly to the studies of interest to them." (DonaldW. Marion, Neurosurgery, Vol. 84 (4), April, 2019)

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Thomas Heldt is the W.M. Keck Career Development Professor in Biomedical Engineering at MIT´s Institute for Medical Engineering & Science. He is also an Associate Professor of Electrical and Biomedical Engineering in MIT´s Department of Electrical Engineering & Computer Science and a Principal Investigator with MIT´s Research Laboratory of Electronics where he directs the Integrative Neuromonitoring and Critical Care Informatics Group.




Dr. Heldt studied Physics at Johannes Gutenberg University, Germany, at Yale University, and MIT. In 2004, he received the PhD degree in Medical Physics from MIT´s Division of Health Sciences and Technology and commenced postdoctoral training at MIT´s Laboratory for Electromagnetic and Electronics Systems.




Dr. Heldt´s research interests focus on signal processing, mathematical modeling, and model identification to support real-time clinical decision making, monitoring of disease
progression, and titration of therapy, primarily in neurocritical and neonatal critical care. In particular, Dr. Heldt is interested in developing a mechanistic understanding of physiologic systems, and in formulating appropriately chosen computational physiologic models for improved patient care. His research is conducted in close collaboration with colleagues at MIT and clinicians from Boston-area hospitals.

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