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This book presents a clear and precise discussion of the biochemistry of eukaryotic cells, particularly those of mammalian tissues, relates biochemical events at a cellular level to the subsequent physiological processes in the whole animal, and cites examples of abnormal biochemical processes in human disease. The organization and content are tied together to provide students with the complete picture of biochemistry and how it relates to human diseases.

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Preface.

Acknowledgments.

PART I: STRUCTURE OF MACROMOLECULES.

1. Eukaryotic Cell Structure

2. DNA and RNA: Composition and Structure

3. Proteins I: Composition and Structure

PART II: TRANSMISSION OF INFORMATION.

4. DNA Replication, Recombination, and Repair

5. RNA: Transcription and RNA Processing

6. Protein Synthesis: Translation and Posttranslational Modifications

7. Recombinant DNA and Biotechnology

8. Regulation of Gene Expression

9. Proteins II: Structure-Function Relationships in Protein Families

10. Enzymes: Classification, Kinetics, and Control

11. The Cytochromes P450 and Nitric Oxide Synthases

12. Biological Membranes: Structure, Receptors, and Solute Transport13. Fundamentals of Signal Transduction

14. Bioenergetics, Mitochondria, and Oxidative Metabolism

15. Carbohydrate Metabolism I: Major Metabolic Pathways and Their Control

16. Carbohydrate Metabolism II: Special Pathways and Glycoconjugates

17. Lipid Metabolism I: Synthesis, Storage, and Utilization of Fatty Acids and Triacylglycerols

18. Lipid Metabolism II: Pathways of Metabolism of Special Lipids

19. Amino Acid and Heme Metabolism

20. Purine and Pyrimidine Nucleotide Metabolism

21. Metabolic Interrelationships

22. Biochemistry of Hormones

23. Molecular Cell Biology

24. Cell Cycle, Programmed Cell Death, and Cancer

25. Digestion and Absorption of Basic Nutritional Constituents

26. Vitamins and Minerals: Requirements and Function

27. Macronutrients: Metabolic Effects and Health Implications

Appendix: Review of Organic Chemistry

Glossary

Index.

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