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Die zweite Auflage dieser bahnbrechenden Publikation zur industriellen asymmetrischen Katalyse fängt die wichtigsten Trends und aktuellen Entwicklungen ein. Komplett neue Fallstudien weltweit führender Fachleute bieten Ihnen einen kompakten und kompetenten Einblick in das Gesamtgebiet.

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Asymmetric hydrogenation: The Monsanto L-dopa process
The other l-dopa process
The Chiral Switch of Metolachlor: The Development of a Large Scale Enantioselective Catalytic Process
An Innovative Asymmetric Sulfide Oxidation: The Process Development History behind the New Antiulcer Agent Esomeprazole
Enantioselective Hydrogenation: Towards a Large-Scale Total Synthesis of Chiral Terpenoid Compounds
Comparison of Four Industrial Syntheses of Ethyl (R)-2-Hydroxy-4-Phenylbutyrate
7-Aminocepholasporanic acid - chemical vs. enzymatic production process
Methods for the Biocatalytic Production of L-Amino Acids on Industrial Scale
The large-scale biocatalytic synthesis of enantiopure cyanohydrins
Industrialization Studies on the Jacobsen Hydrolytic Kinetic Resolution of Racemic Epoxides
Scale-up studies in asymmetric transfer hydrogenation
Practical Applications on Biocatalysis or the Manufacturing of Chiral alcohols such as (R)-1,3-butanediol by Stereo-specific Oxidoreduction
Microbial resolution of 2,3-dichloro-1-propanol and 3-chloro-1,2-propanediol
Synthesis of Unnatural Amino Acids
The Application of DuPHOS Rhodium(I) Catalysts for Commercial Scale Asymmetric Hydrogenation
(TMBTP) Ruthenium catalysts: a useful tool for industrial asymmetric hydrogenations
Biocatalytic approaches for large scale production of asymmetric synthons
Master the scale-up of catalytic asymmetric hydrogenations for the manufacture of fine chemicals
Large-Scale Applications of Biocatalysis in the Asymmetric Synthesis of Laboratory Chemicals
Development of an Efficient Synthesis of Chiral 2-Hydroxy Acids
Factors Influencing the Application of Literature Methods Toward the Preparation of a Chiral trans-Cyclopropane Carboxylic Acid Intermediate During Development of a Melatonin Agonist
Hetero Diels-Alder - Biocatalysis Approach for the Synthesis of (S)-3-[2-{(Methylsulfonyl) oxy}ethoxy]-4-(triphenylmethoxy)-1-butanol Methanesulfonate: Successful Application of an Enzyme Resolution ProcessMulti kilo resolution of XU305, a key intermediate to the platelet glycoprotein Iib/IIIa receptor antagonist roxifiban via kinetic and dynamic enzymatic resolution
Protease-Catalyzed Preparation of (S)-2-[(tert-Butylsulfonyl)methyl]-hydrocinnamic Acid for Renin Inhibitor RO0425892
Protease-Catalyzed Preparation of Chiral 2-Isobutyl Succinic Acid Derivatives for Collagenase Inhibitor RO0319790
Development of a Biocatalytic Process for the Resolution of (R)- and (S)-Ethyl 3-amino-4-pentynoate Isomers Using Enzyme Penicillin acylase

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This second edition of the pioneering work on this hot topic captures the major trends and latest achievements in the art of asymmetric catalysis on an industrial scale. A number of completely new real-life case studies written by the world leaders in their respective areas provide a compact and qualified insight into this developing field. The resulting ready reference and handbook collates first-hand and valuable information within a context where it can be easily found.
The high-quality contributions illustrate the relevant environments and situations, such as time pressure, how the catalytic step fits into the overall synthesis, or competition with other synthetic approaches, as well as the typical problems encountered in the various phases, including finding/developing the catalyst and optimization of the process or choice of equipment. Both successful and unsuccessful approaches to solve these problems are described.

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