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Lipids are vital constituents of cell membranes and have been shown essential for synaptic formation and remodeling. These processes are crucial for learning, formation of memories and neuronal repair, all of which are progressively impaired during normal and pathological aging, especially in dementias of the Alzheimer´s disease (AD) type. Across the globe, interest in research on the interconnections between the lipidic system and AD is growing. Based on pathologic and genetic findings, this book explores the possible roles of paraoxonase 1 in AD, an antioxidant enzyme found on lipoprotein particles transporting lipids to neurons. Of interest to scholars, the current book also provides a comprehensive up-to-date review of the role of brain lipid metabolism in the pathogenesis of AD.

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Valérie Leduc has worked extensively in health sciences for the past eleven years and has received several awards for her accomplishments, including a Governor General´s Academic Medal. She is currently pursuing her Doctor of Philosophy degree at McGill University where she earned her Master of Sciences degree in 2009.

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