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To celebrate its 5th edition, the International Symposium on Biomedical S- ulation (ISBMS) was organized in conjunction with the International Meeting on Simulation in Healthcare (IMSH). IMSH is the premier simulation in heal- care meeting and largestsingle gathering of clinicians, educators,administrators and other simulation stakeholders. This unique link-up aimed at bringing - gether simulation users with those involved in its scienti?c and technological developments in order to foster closer interaction. The joint meeting was held in Phoenix, Arizona during January 23 24, 2010. Biomedical modeling and simulation are at the center stage of worldwide e?orts to understand and replicate the behavior and function of the human organism. The Physiome Project and Virtual Physiological Human (VPH) i- tiative aim to develop advanced computational models that will facilitate the understanding of the integrative function of cells, organs, and organisms, with the ultimate goal of delivering truly personalized medicine. At the same time, progressinreal-timebiomedicalmodeling andsimulationhasenabledmorec- plex, interactive simulations, o?ering the possibility of highly sophisticated task trainers,proceduralandpatientsimulatorsto supportmedicaltrainingandsafer clinical practice. It is in this contextthat ISBMS seeks to act as an international forum for researchers in this increasingly important area to share their latest work, discuss future trends and forge new collaborations.

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Soft Tissue Properties.- LASTIC: A Light Aspiration Device for in vivo Soft TIssue Characterization.- Characterization of Suction and CUSA Interaction with Brain Tissue.- Evaluation of a Technique to Estimate the Compliance of Atherosclerotic Intima.- Quantifying Mechanical Properties in a Murine Fracture Healing System Using an Inverse Geometric Nonlinear Elasticity Modeling Framework.- Modeling and Segmentation.- Optimization of Case-Specific Vascular Tree Models Based on Vessel Size Imaging.- Efficient Generation of Corresponding Meshes for Biomedical Flow Simulations.- Solid Mesh Registration for Radiotherapy Treatment Planning.- Physics-Based Modeling of the Pregnant Woman.- Semi-automatic Segmentation of Fractured Pelvic Bones for Surgical Planning.- Simulation of Biophysical Processes.- Development of a Computer Simulation Tool for Application in Adolescent Spinal Deformity Surgery.- A Fluid-Structure Interaction Index of Coronary Plaque Rupture.- Biomechanical Simulation of Human Eye Movement.- A Theoretical Model for RF Ablation of Kidney Tissue and Its Experimental Validation.- A Point-Based Simulation Framework for Minimally Invasive Surgery.- Real-Time Interactive Simulation.- Six Degree-of Freedom Haptic Rendering for Dental Implantology Simulation.- Haptic Simulator for Prostate Brachytherapy with Simulated Ultrasound.- A Shell Model for Real-Time Simulation of Intra-ocular Implant Deployment.- Endovascular Guidewire Flexibility Simulation.- Comparing Automatic Simulator Assessment with Expert Assessment of Virtual Surgical Procedures.

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