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Katrin Wolff

Protein structure prediction and folding dynamics


An investigation of protein structure and folding using structural profiles
2010. 108 S. 220 mm
Verlag/Jahr: SÜDWESTDEUTSCHER VERLAG FÜR HOCHSCHULSCHRIFTEN 2010
ISBN: 3-8381-1520-1 (3838115201)
Neue ISBN: 978-3-8381-1520-7 (9783838115207)

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Proteins carry out a variety of vital functions in every living organism, ranging from enzyme proteins regulating biochemical reactions to motor proteins causing the contraction and movement of muscles. The three-dimensional shape of proteins is crucial for their biological function. This book investigates the protein folding problem from two different angles. The first is the question how a protein´s amino acid sequence determines its structure, the second aspect is the physical process of protin folding. Both questions are addressed using so-called structural profiles as one-dimensional representations of protein structure.
After graduating from the Technische Universität Darmstadt in 2007 with a diploma in Physics, Katrin Wolff wrote her dissertation on protein structure and folding under the supervision of Prof. M. Porto. She received her doctoral degree in 2010.