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Body weight, yolk sac weight, yolk sac/body weight index, estimated yolk sac absorption and chemical composition of yolk should be studied as important parameters when determining the factors for yolk sac infection in chicks. Effect of different types of feed showed that simple commercial starter ration give better results as initial feed in broilers infected with E. coli infection rather than using wheat bran, ground maize, 2% glucose solution with CSR, 6% canola oil with CSR or enzymes with CSR. Feeding commercial starter ration in E. coli infection, in early life of chick can led to increase weight gain, decrease in yolk sac weight and yolk sac/body weight index, increased estimated yolk absorption and better absorption of moisture and protein from yolk. Early chick mortality should be controlled to avoid economic losses in commercial poultry farming

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