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Abhishek Patidar, Narendra Singh Lodhi, Pushpendra Kumar Vishwakarma (Beteiligte)

REPIMELTS AND ITS SPECIAL PERSPECTIVES


formulations and its developments
2011. 136 S.
Verlag/Jahr: VDM VERLAG DR. MÜLLER 2011
ISBN: 3-639-35565-2 (3639355652)
Neue ISBN: 978-3-639-35565-9 (9783639355659)

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Tablet is the most popular among all dosage forms existing today because of its convenience of self administration, compactness and easy manufacturing; however hand tremors, dysphasia in case of geriatric patients, the underdeveloped muscular and nervous systems in young individuals and h case of uncooperative patients, the problem of swallowing is common phenomenon which leads to poor patient compliance To overcome these drawbacks, mouth dissolving tablets (MDT) or orally disintegrating tablets; (ODT) has emerged as alternative oral dosage forms. These are novel types; of tablets that disintegrate/dissolve/ disperse in saliva within few seconds´. According to European Pharmacopoeia, the ODT should disperse/disintegrate in less than three minutes. The basic approach used in development of MDT is the use of superdisintegrants like Cross linked carboxymelhylcellulose (Croscarmeliose), Sodium starch glycol ate (Primogel, Explotab). Polyvinylpyrrolidone (Polyplasdone) etc. which provide instantaneous disintegration of tablet after putting on tongue, thereby releasing the drug in saliva.