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A total of 9 experiments were carried out at different doses (100, 200 and 400 mg/kg, p.o.) of Dhatri Lauha(DTR)which was studied in different animal model to find out the various degrees of significant action of the drug on mice (Swiss-Webster strain, 20-40 gm body weight). Highly significant (p=0.009) increase in ambulation behavior was observed in Hole board test and highly significant (p=0.005) increase in motor activity was observed in Hole cross test. Open field test showed significant (p=0.036) increase in Standing up behavior. Climbing out test produced a significant (p=0.039) decrease in activity. All these experiment were performed to ensure the safety of the general patients or users of the society and country as a whole. In conclusion, it can be suggested that this DTR can be prescribed for treating different diseases without or with a minimal central nervous system side-effect.

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Nishat Nasrin (Senior Lecturer, Dept. of Pharmacy, East West University) and Muhammad Asaduzzaman (Lecturer, Dept. of Clinical Pharmacy and Pharmacology, University of Dhaka) completed their Masters of Pharmacy (M.Pharm.) from the Dept. of Clinical Pharmacy and Pharmacology, University of Dhaka. Habib A. Md. Shakil completed B.Pharm. in Pharmacy.

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