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In modern ecotoxicology, fish have become the major vertebrate model, and a tremendous body of information has been accumulated.
This volume attempts to summarize our present knowledge in several fields of primary ecotoxicological interest ranging from the use of (ultra)structural modifications of selected cell systems as sources of biomarkers for environmental impact over novel approaches to monitoring the impact of xenobiotics with fish in vitro systems such as primary and permanent fish cell cultures, the importance of early life-stage tests with fish, the bioaccumulation of xenobiotics in fish, the origin of liver neoplastic lesions in small fish species, immunocytochemical approaches to monitoring effects in cytochrome P450-related biotransformation, the impact of heavy metals in soft water systems, the environmental toxicology of organotin compounds, oxidative stress in fish by environmental pollutants to effects by estrogenic substances in aquatic systems.

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Fish cell lines as a tool in aquatic toxicology.- Primary cell cultures from fish in ecotoxicology.- Cytological alterations in fish hepatocytes following in vivo and in vitro sublethal exposure to xenobiotics - structural biomarkers of environmental contamination.- Architectural pattern, tissue and cellular morphology in livers of fishes: Relationship to experimentally-induced neoplastic responses.- Immunochemical approaches to studies of CYP1A localization and induction by xenobiotics in fish.- "Oxidative stress" in fish by environmental pollutants.- Origin of cadmium and lead in clear softwater lakes of high-altitude and high-latitude, and their bioavailability and toxicity to fish.- Effects of organotin compounds in fish: from the molecular to the population level.- Multiple stressors in the Sacramento River watershed.- Effects of estrogenic substances in the aquatic environment.- Testing of chemicals with fish - a critical evaluation of tests with special regard to zebrafish.- Bioaccumulation of contaminants in fish.

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Bruno Streit ist Professor am Institut für Ökologie, Evolution und Diversität. Er lehrt seit 1985 an der Universität Frankfurt am Main und ist Sprecher des Kompetenzverbunds Biodiversität Frankfurt (BioFrankfurt).

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