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´This book describes and summarizes the radiation responses of both normal and neoplastic tissues with a focus on rational strategies for the modification of these responses. Emerging data from molecular oncology and radiobiology are reviewed in depth. The book covers not only general principles of radiation-induced reactions but also a large number of preclinical and clinical data that will guide the reader through this complex and dynamic field and will provide valuable information for the development of further research projects.

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Normal Tissues: Role of Radiation-Induced Signaling Proteins in the Response of Repopulating Normal Tissues (K.-R. Trott); Role of Radiation-Induced Signaling Proteins in the Response of Vascular and Connective Tissues (H.-P. Rodemann); Pathogenetic Mechanisms of Lung Fibrosis (W. Doerr et al.); Strategies for Modification of the Radiation Response of the Lung (E.L. Travis); Strategies for Modification of the Radiation Response of Gastrointestinal Organs (M. Hauer-Jensen); Mechanisms and Modification of the Radiation Response of the CNS; Haematopoetic Tissue I: Response Modification by EPO (J. Dunst); Haematopoetic Tissue II: Role of Colony-Stimulating Factors (G. Wagemaker); Oral Mucosa: Response Modification by Keratinocyte Growth Factor (W. Doerr); Malignancies: Role of Growth Factors in Tumor Growth and Progression (incl. GYN Tumors) (A. W. Fyles); CNS Tumors (C. Nieder/J. Schlegel); Lung, Head and Neck, GI Tumors (G. Stüben/ M. Stuschke); Role of Signalling Pathway Modification (O. Riesterer/S. Bodis); Anti-VEGT Strategies plus Radiotherapy (D. Zips/M. Baumann); Anti-EGFR Strategies plus Radiotherapy (L. Milas); Enhancement of the Radiation Response with Interleukins/Interferons (F. Lohr); Enhancement of the Radiation Response with TNF/TRAIL (R.E. Meyn); Enhancement of the Radiation Responses with COX-2 Inhibitors (L. Milas/K. Kian Ang); Enhancement of the Radiation Response with Farnesyltransferase Inhibitors (E.J. Bernhard et al.); Subject Index. List of Contributors.

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From the reviews:

"This excellent volume gives an insight into the progress that has been made in the study of processes that control the response of cells to radiation exposure. ... This is a scholarly work and both the content and presentation are of a very high standard. I would highly recommend this as a reference book to radiotherapy departments who wish to remain informed in this rapidly developing area." (Dr M Casey, RAD Magazine, September, 2003)

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