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´Part 1 - Near Infrared Spectroscopy
Chapter 1
The Western Reserve, Edward Morley and Oxygen

Chapter 2
Analysis of the Changes in the Oxidation of Brain Tissue Cytochrome c Oxidase in Traumatic Brain Injury Patients during Hypercapnoea: A Broadband NIRS Study

Chapter 3
Effects of Assuming Constant Optical Scattering on Haemoglobin Concentration Measurements using NIRS during a Valsalva Manoeuvre

Chapter 4
Speech Therapy Changes Blood Circulation and Oxygenation in the Brain and Muscle. A Near-Infrared Spectrophotometry Study

Part 2 - Oxygen Sensors and Measurement
Chapter 5
Evaluation of Lithium Naphthalocyanine (LiNc) Microcrystals for Biological EPR Oximetry

Chapter 6
Challenges to Intestinal pO2 Measurement Using EPR

Chapter 7
Quantification of Systemic Interference in Optical Topography Data during Frontal Lobe and Motor Cortex Activation: An Independent Component Analysis

Chapter 8
Measuring Oxygen in Living Tissue: Intravascular, Interstitial and "Tissue" Oxygen Measurements

Chapter 9
Cerebral Oxygenation of the Cortex and Striatum following Normobaric Hyperoxia and Mild Hypoxia in Rats by EPR Oximetry Using Multi-Probe Implantable Resonators

Chapter 10
31P-MRS Studies of Melanoma Xenograft Metastatic Potential

Chapter 11
Modulation of Tumor Hypoxia by Topical Formulations with Vasodilators for Enhancing Therapy

Part 3 - Blood and Blood Substitutes
Chapter 12
MP4, A Vasodilatory PEGylated Hemoglobin

Chapter 13
Zymogen Protein C to Prevent Clotting Without Bleeding During Invasive Medical Procedures

Part 4 - Tumor Biology
Chapter 14
Oxygenation Status of Urogenital Tumors

Chapter 15
Tumor pO2 as a Surrogate Marker to Identify Therapeutic Window during Metronomic Chemotherapy of 9L Gliomas

Chapter 16
Hypoxia-induced Extracellular Acidosis Increases p-glycoprotein activity and chemoresistance in tumors in vivo via p38 signaling pathway

Chapter 17
Evidence Against a Major Role for TKTL-1 in Hypoxic and Normoxic Cancer Cells

Chapter 18
NMR Metabolic and Physiological Markers of Therapeutic Response

Chapter 19
Characterizing Breast Cancer Mouse Xenografts with T1p-MRI: A Preliminary Study

Chapter 20
Effect of AEM Energy Applicator Configuration on Magnetic Nanoparticle Mediated Hyperthermia for Breast Cancer

Chapter 21
Highly Specific, NIR Fluorescent Contrast Agent with Emission Controlled by Gold Nanoparticle

Part 5 - Presidential Symposium
Chapter 22
Oral Pioglitazone Reduces Infarction Volume and Improves Neurologic Function Following MCAO in Rats

Part 6 - Angiogenesis
Chapter 23
Chronic Mild Hypoxia Ameliorates Chronic Inflammatory Activity in Myelin Oligodendrocyte Glycoprotein (MOG) Peptide Induced Experimental Autoimmune Encephalomyelitis (EAE)

Chapter 24
Effect of Oxygenation on Stem-Cell Therapy for Myocardial Infarction

Part 7 - Mitochondrial Metabolism
Chapter 25
Regulation of Cytosolic and Mitochondrial Oxidation via Malate-Aspartate Shuttle: An Observation Using Dynamic 13C NMR Spectroscopy

Chapter 26
In Vivo Assessment of Oxygen Consumption via Deuterium Magnetic Resonance

Chapter 27
Elevated Mitochondrial DNA Copy Number and POL-_ Expression but decreased Expression of TFAM in Murine Intestine following Therapeutic Dose Irradiation

Chapter 28
Heterogeneity of Mitochondrial Redox State in Premalignant Pancreas in a PTEN Null Transgenic Mouse Model

Chapter 29
Potential Application of 17O MRI to Human Ischemic Stroke

Part 8 - Development
Chapter 30
Fetal Cerebral Oxygenation: The Homeostatic Role of Vascular Adaptations to Hypoxic Stress

Chapter 31
Impaired Cerebral Autoregulation Using Near-Infrared Spectroscopy and its Relation to Clinical Outcomes in Premature Infants

Part 9 - Systems Modeling
Chapter 32
Variable ATP Yields and Uncoupling of Oxygen Consumption in Human Brain

Chapter 33
Interpretation of NMR Spectroscopy Human Brain Data with Multi-Compartment Computational Mo

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This book covers all aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism. Special attention will be paid to methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. This book is multidisciplinary and designed to bring together experts and students from a range of research fields including biochemical engineering, physiology, microcirculation, and hematology.

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