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This unique volume shows how specific foods and food groups enhance nitric oxide (NO) bioactivity in the body through various means, and how this relates to normal physiology, examining connections between foods that enhance NO bioactivity, and human health.

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Nitrite and Nitrate in Human Health and Disease delivers a comprehensive review of nitrite and nitrate biology, from basic biochemistry to the complex physiology and metabolism of these two naturally occurring molecules in the human body. Well-organized and well referenced chapters cover the rich history of nitrite and nitrate, sources of exposure, and the physiological effects when consumed through foods containing nitrite and nitrate. The chapters are written by leading experts, all of whom share their research and perspectives in order to help define the context for benefits vs. any potential risks associated with nitrite and nitrate use, either through dietary ingestion or therapeutic dosing. This diverse collection of authors includes vascular biologists, physiologists, physicians, epidemiologists, cancer biologists, registered dieticians, chemists, and public health experts from five countries in both academia and government. Nitrite and Nitrate in Human Health and Disease provides a balanced view of nitric oxide biochemistry, and nitrite and nitrate biochemistry in physiology and in the food sciences.

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1. Introduction - Co-Editors: Nathan S. Bryan, Ph.D., Joseph Loscalzo, M.D, Ph.D. 2. From Atmospheric Nitrogen to Bioactive Nitrogen Oxides - Mark Gilchrist, Ph.D., Nigel Benjamin, M.D. 3. The Nitrate-Nitrite-Nitric Oxide Pathway in Mammals - Jon Lundberg, M.D., Ph.D. Eddie Weitzberg M.D., Sruti Shiva, Ph.D., Mark Gladwin M.D. 4. Sources of Exposure to Nitrogen Oxides - Andrew Milkowski, Ph.D. Section 2: FOOD AND ENVIRONMENTAL EXPOSURES TO NITRITE AND NITRATE 5. History of Nitrite and Nitrate in Foods - Jimmy Keeton, Ph.D. 6. Nutritional Epidemiology of Nitrogen Oxides: What do the Numbers Mean? - Martin LaJous, M.D., Walter Willet, M.D, MPH. 7. Nutritional Impact on the Nitric Oxide Pathway - Wing Tak Wong, Ph.D., John Cooke, M.D., Ph.D. 8. Dietary Flavonoids as Modulators of NO bioavailability in Acute and Chronic Cardiovascular Disease - Matthias Totzeck, M.D., Malte Kelm, M.D., Ph.D., Tienush Rassaf, M.D., Ph.D. 9. Nitrite and Nitrate in Human Breast Milk: Implications for Development - Pamela D. Berens, M.D., Nathan S. Bryan, Ph.D. 10. Regulation of Dietary Nitrate and Nitrite: Balancing Essential Physiological Roles with Potential Health Risks - Norman Hord, Ph.D., R.D. Section 3: NITRITE AND NITRATE IN THERAPEUTICS AND DISEASE 11. Nitric Oxide Signaling in Health and Disease - Nathan S. Bryan, Ph.D., Jack Lancaster, Ph.D. 12. Inhaled Nitric Oxide - Kenneth Bloch, M.D., Andrea Steinbicker, M.D., Lisa Lohmeyer, Rajeev Malhotra, M.D. 13. Pharmacology of Nitrovasodilators - Nathaniel Page, Pharm D., Ho-Leung Fung, Ph.D. 14. Nitrite and Nitrate in Ischemia-Reperfusion Injury - Madhav Lavu, M.D., Susheel Gundewar, M.D., David Lefer, Ph.D. 15. The Nitrate-Nitrite-Nitric Oxide Pathway in Traditional Herbal Medicine for Heart Disease - Yong Jian Geng, M.D., Ph.D. 16. Nitrite and Nitrate in Cancer - David M. Klurfeld, Ph.D. 17. Looking Forward - Co-Editors: Nathan S. Bryan, Ph.D., and Joseph Loscalzo, M.D., Ph.D.

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