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Y. Damodar Singh

Immunotoxicity of Eupatorium adenophorum (Sticky snakeroot) in mice


A mice model study
2013. 68 S. 220 mm
Verlag/Jahr: SCHOLAR´S PRESS 2013
ISBN: 3-639-70595-5 (3639705955)
Neue ISBN: 978-3-639-70595-9 (9783639705959)

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Eupatorium adenophorum is considered to be a serious weed in agriculture, especially in rangelands where it often replaces either the more-desirable vegetation or native species, but also in forests. Grazing animals get accidentally exposed to the plant under scarcity conditions. It is generally unpalatable to grazing animals, but goats graze on this plant infrequently. It is fatally toxic to horses and causes the blowing disease in Hawaii and Numinbah disease or Tollebudgera horse disease in Australia. Toxicopathological studies were taken up in Swiss albino mice, as a model and the effects of the plant extract on immunological parameters were recorded. The results of the present studies on humoral immune responses suggest that the highest dose of the plant extract might probably be having some immune-suppressant effects on the primary (IgM) and secondary (IgG) immune responses and also some immunosuppressant effects on cell-mediated immunity (CMI) of mice.
He did his B.V.Sc. & A.H. and M.V.Sc. (Veterinary Pathology) in 1991 and 1993 from BCKV, West Bengal and Ph.D. in 2012 from WBUAFS, Kolkata (INDIA). He served as Veterinary Officer in the fields for 7 years and joined the College of Vety. Sciences, Central Agricultural University, Aizawl, Mizoram (INDIA) in October, 2001 as Assistant Professor.