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This is the third workshop on this topic that took place in Crete from May 27 to June 1, 2005. Similar to the two previous workshops, held in Santorini October 2000 and 2002 respectively, the purpose of this workshop is to bring together scientists from all over the world to discuss their latest findings on the various aspects of lymphocyte signal transduction. The participants represented academia, industry, foundation and governmental laboratories.

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Protein Kinase C-Theta (PKC?): New Perspectives on Its Functions in T Cell Biology.- Travel Informations on the TEC Kinases during Lymphocyte Activation.- Inducible T Cell Tyrosine Kinase (ITK): Structural Requirements and Actin Polymerization.- Differential Requirements of PI3K Subunits for BCR or BCR/CD19-Induced ERK Activation.- Protein Tyrosine Phosphatases in Human Disease.- The T Cell-Specific Adapter Protein Functions as a Regulator of Peripheral but not Central Immunological Tolerance.- Proximal Signals Controlling B-Cell Antigen Receptor (BCR) Mediated NF-?B Activation.- The Adapter 3BP2: How It Plugs into Leukocyte Signaling.- CTLA-4 Regulation of T Cell Function via RAP-1-Mediated Adhesion.- Protein Crosstalk in Lipid Rafts.- Role of Lipid Rafts in Activation-Induced Cell Death : The Fas Pathway in Aging.- T Cell Response in Aging: Influence of Cellular Cholesterol Modulation.- Lymphocyte Signaling and the Translatability of mRNA.- Protein Arginine Methylation: A New Frontier in T Cell Signal Transduction.- Immune Regulation by Ubiquitin Conjugation.- CTIB (C-Terminus Protein of I?B-?: A Novel Factor Required for Acidic Adaptation.- HIV May Deplete Most CD4 Lymphocytes by a Mechanism Involving Signaling through its Receptors on Non-Permissive Resting Lymphocytes.- Integrating Traditional and Postgenomic Approaches to Investigate Lymphocyte Development and Function.- Phosphoproteomic Analysis of Lymphocyte Signaling.

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