This book targets custom IC designers who are encountering variation issues in their designs, especially for modern process nodes at 45nm and below. It sets out state-of-the-art variation-aware design tools that will help them fix their problems efficiently.Introduction.- Fast PTV Verification and Design.- Pictoral Primer on Probablilities.- 3-Sigma Verification and Design.- High-Sigma Verification and Design.- Variation-Aware Design.- Conclusion.