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Meghasham Narule, Vibha Nikose
(Beteiligte)
Sonochemical synthesis
2014. 144 S. 220 mm
Verlag/Jahr: SCHOLAR´S PRESS 2014
ISBN: 3-639-66498-1 (3639664981)
Neue ISBN: 978-3-639-66498-0 (9783639664980)
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Imidazoles have always manifested fascinating biological properties and many of these molecules have been individually elaborated to pharmaceuticals. They represent one of two major classes of antifungal azole derivatives: the imidazole group has contributed significantly to the therapy of both superficial and systemic mycotic infections. Azaheterocycles constitute a very important class of compounds. In particular, pyrimidine derivatives include a large number of natural products, pharmaceuticals, and functional materials. While development of important methodologies for the synthesis of pyrimidines enjoys a rich history, the discovery of new strategies for the convergent synthesis of pyrimidines remains a vibrant area of chemical research. Azetidin, -azetin, 2-azetin and azete are the nitrogen analogues of cyclobutane, cyclobutene and cyclobutadiene respectively. To overcome the -lactam resistance there are several ideas; to develop new class of antibiotics unsusceptible to the resistant mechanisms, alter the structure of the - lactams, rendering them insensitive to hydrolysis, use of hybrid drugs which can kill bacteria.
Dr. Meghasham N. NaruleM. Sc., M. Ed., MBA(HR), Ph.D. Head, Department of Chemistry,Vidya Vikas Arts, Commerce & Science, College, Samudrapur,442305, India.Dr. Vibha M. NikoseM. Sc., Ph.D. Department of Chemistry,Institute of Science,Civil Lines, Nagpur, MS. 440001