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Optic neuritis (ON) is one of the common first manifestations of multiple sclerosis (MS). Manuscript data demonstrates involvement of peripheral blood B-cell sub-population during the first episode of acute ON in MS patients. The findings approve a significant role of B lymphocytes in the pathogenesis of the first episode of acute ON. Research data and conclusions could be useful for core understanding of MS pathogenesis and would be successful application in clinical practice of early ON treatment.

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Dr. Feldman was born in the USSR to a family of doctors. Even at the beginning of her career she became interested in neurobiology. Her study was continued at Tel Aviv University (Campus Sheba hospital, Israel) where she received her PhD degree in MS researchProf. Anat Achiron, Director of the MS Center (Sheba Medical Center, Israel) - well-known neurologist and researcher of Multiple Sclerosis. Her works shed new lights on the pathogenesis and therapy of MS.

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