 Neuerscheinungen 2014Stand: 2020-02-01 |
Schnellsuche
ISBN/Stichwort/Autor
|
Herderstraße 10 10625 Berlin Tel.: 030 315 714 16 Fax 030 315 714 14 info@buchspektrum.de |

Andrea Bighinati
Dopamine concentration in mouse intracerebral microdialysis study
A new analytical method to determine Dopamine and Acetylcholine concentration in intracerebral microdialysis
2014. 68 S. 220 mm
Verlag/Jahr: EDIZIONI ACCADEMICHE ITALIANE 2014
ISBN: 3-639-77844-8 (3639778448)
Neue ISBN: 978-3-639-77844-1 (9783639778441)
Preis und Lieferzeit: Bitte klicken
Dopaminergic neurons located in the ventral midbrain are essential for the control of diverse cognitive and motor behaviors and are associated with multiple psychiatric and neurodegenerative disorders, jointly with drug addiction. Three anatomically and functionally distinct subgroups of midbrain dopaminergic neurons have been identified (A8-A10) which give rise to prominent forebrain projections (i.e. mesostriatal, mesocortical and mesolimbic pathways), each one with a different behavioral role. The mesolimbic pathway is involved in drug addiction and there is overwhelming evidence that most of the drugs of abuse, such as: cocaine, amphetamine and even nicotine, increase dopamine transmission in limbic regions of the brain through different mechanisms. The nucleus accumbens (NAc) is the major target of mesolimbic pathway and dopamine release in this area is stimulated after systemic administration of all addictive drugs in mouse. Quantification of dopamine (DA) concentration in in-vivo intracerebral microdialysis study plays a critical role for determination of the effects of drugs in mesolimbic system. Classically, determination of dopamine concentration in microdialysis samples
Andrea Bighinati was born in Ferrara, Italy, on September 11th, 1988. He has obtained his master degree in Medical and Pharmaceutical Biotechnology at the University of Modena and Reggio Emilia in 2012 with the higher score.