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Hassan Errami

Efficient Methods for Symbolic Analysis of Complex Reaction Networks


2014. 108 S. 220 mm
Verlag/Jahr: SÜDWESTDEUTSCHER VERLAG FÜR HOCHSCHULSCHRIFTEN 2014
ISBN: 3-8381-3970-4 (3838139704)
Neue ISBN: 978-3-8381-3970-8 (9783838139708)

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In this Book, we mainly present efficient algorithmic methods to detect Hopf bifurcation fixed points in (bio)-chemical reaction networks with symbolic rate constants, thereby yielding information about their oscillatory behavior of the networks. The methods use the representations of the systems on convex coordinates that arise from stoichiometric network analysis. One of the methods called HoCoQ reduces the problem of determining the existence of Hopf bifurcation fixed points to a first-order formula over the ordered field of the reals that can then be solved using computational-logic packages. The second method called HoCaT uses ideas from tropical geometry to formulate a more efficient method that is incomplete in theory but worked very well for the attempted high-dimensional models involving more than 20 chemical species. We also study Muldowney´s extension of the classical Bendixson-Dulac criterion for excluding periodic orbits to higher dimensions for polynomial vector fields and we discuss the use of simple conservation constraints and the use of parametric constraints for describing simple convex polytopes on which periodic orbits can be excluded.
Hassan Errami was born in Tanalt (Morocco) and moved 1999 to Germany. Since 2010, he is a member of the research group Multimedia, Simulation and Virtual Reality at the institute for informatics in Bonn. He received his PhD (Dr. rer. nat) in mathematics from the university of Kassel and his MS in computer science from the university of Bonn.