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Concisely discussing the application of high throughput analysis to move forward our understanding of microbial principles, Metagenomics for Microbiology provides a solid base for the design and analysis of omics studies for the characterization of microbial consortia. The intended audience includes clinical and environmental microbiologists, molecular biologists, infectious disease experts, statisticians, biostatisticians, and public health scientists. This book focuses on the technological underpinnings of metagenomic approaches and their conceptual and practical applications.

With the next-generation genomic sequencing revolution increasingly permitting researchers to decipher the coding information of the microbes living with us, we now have a unique capacity to compare multiple sites within individuals and at higher resolution and greater throughput than hitherto possible. The recent articulation of this paradigm points to unique possibilities for investigation of our dynamic relationship with these cellular communities, and excitingly the probing of their therapeutic potential in disease prevention or treatment of the future.

Expertly describes the latest metagenomic methodologies and best-practices, from sample collection to data analysis for taxonomic, whole shotgun metagenomic, and metatranscriptomic studies
Includes clear-headed pointers and quick starts to direct research efforts and increase study efficacy, eschewing ponderous prose
Presented topics include sample collection and preparation, data generation and quality control, third generation sequencing, advances in computational analyses of shotgun metagenomic sequence data, taxonomic profiling of shotgun data, hypothesis testing, and mathematical and computational analysis of longitudinal data and time series. Past-examples and prospects are provided to contextualize the applications.

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Preface

Steps in Metagenomics: Let´s Avoid Garbage In and Garbage Out
Long-Read, Single Molecule, Real-Time (SMRT) DNA Sequencing for Metagenomic Applications
Ribosomal RNA Removal methods for Microbial Transcriptomics
High Throughput Sequencing as a Tool for Exploring the Human Microbiome
Computational Tools for Taxonomic Microbiome Profiling of Shotgun Metagenomics
Hypothesis Testing of Metagenomic Data
Longitudinal Microbiome Data Analysis
Metagenomics for Bacteriology
Toward the Understanding of the Human Virome
Promises and Prospects of Microbiome Studies
Glossary

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".an excellent book on the latest metagenomic methodologies and best practices in sample collection to data analysis for metagenomic and metatranscriptomic studies. Score: 80 - 3 Stars" -- Doody´s

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