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The burden of cutaneous drug reactions is significant, in both outpatient and inpatient settings, and can result in morbidity and even mortality. This book is unique in its approach to this problem. This text is divided into basic principles, common drug reactions, skin conditions mimicked by drug reactions, drug reactions to the skin appendages, life-threatening drug reactions, less common drug reactions, and special groupings of drug reactions. For the clinician, the skin can only morphologically react in to many limited ways. This is also true for the pathologist. Combining these two forever linked specialties is a synergistic paradigm that greatly enhances diagnosis, and ultimately therapy, for these pernicious conditions. Drug reactions in the skin remain a common complication of therapy. True incidences of drug reactions are not available. For general discussion, the rule of 3% can be applied with reasonable assuredness. Approximately 3% of all hospitalized patients develop an adverse cutaneous drug reaction. Approximately 3% of these reactions are considered severe. Outpatient data is even more obscure, but at least 3% of dermatology clinic outpatient visits are due to a drug reaction. Cutaneous drug reactions compromise approximately 3% of all drug reactions. Even more challenging is the fact that the most vulnerable populations to drug reactions are increasing and include the elderly patients on prolonged drug therapy, and patients that use multiple drugs at the same time.

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Immunology of Cutaneous Drug Eruptions.- Principles of Diagnosis of Cutaneous Drug Eruptions.- Histopathology of Drug Reactions.- Principles of Treatment of Cutaneous Drug Eruptions.- Morbilliform Drug Eruptions.- Drug-Induced Urticaria.- Erythema Multiforme and Drug Reactions.- Drug-Induced Vasculitis.- Pigment Changes and Drug Reactions.- Drug-induced Photosensitivity.- Erythema Nodosum as a Drug Eruption.- Lichen Planus Drug Reactions.- Pityriasis Rosea-Like Drug Eruptions.- Psoriasiform Drug Eruptions and Drugs that Flare Psoriasis.- Acne and Drug Reactions.- Collagen Vascular Diseases and Cutaneous Drug Reactions.- Fixed Drug Eruptions.- Autoimmune Bullous Diseases and Drugs.- Lymphoma and Pseudolymphoma and Drug Reactions.- Drug-Induced Alopecia.- Drug Eruptions of the Scalp.- Drug Reactions in the Nail in Cutaneous Drug Eruptions.- Drug Eruptions and Generalized Exfoliative Erythroderma.- Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.- Drug-induced Delayed Multi-organ Hypersensitivity Syndrome.- Acute Generalized Exanthematous Pustulosis.- Cutaneous Drug Reactions to Anticoagulants.- Antiepileptic Medications and Cutaneous Drug Reactions.- Chemotherapy and Cutaneous Drug Reactions.- Tyrosine Kinase Medications and the Skin.- Medical Therapies and Their effects on Skin Cancer.- Cutaneous Reactions to BRAF Inhibitors.- Cutaneous Reactions to Corticosteroids.- Cutaneous Reactions to Retinoids.- Neutrophilic Dermatoses.- Granulomatous Drug Reactions.- Cutaneous Drug Reactions in Patients Infected with Human Immunodeficiency Virus.- Pediatric Drug Eruptions of the Skin.

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"This book describes the pathophysiology of different drug rashes of different etiology with a special insight into drug hypersensitivity reactions. ... Those physicians (allergists, dermatologists, pathologists, etc.) who desire a more in-depth look at the interaction of drugs and the skin, as well as the underlying mechanisms that lead to cutaneous drug eruptions, will find in this book a comprehensive and up-to-date valuable medical reference." (Alberto Alvarez-Perea, World Allergy Organization WAO, worldallergy.org, January, 2016)

"This book discusses the underlying immunopathology and histology responsible for the patterns of drug rashes. ... The audience is dermatologists and primary care physicians. ... The authors do an outstanding job of helping track down the villainous drug. If you are interested in honing your Sherlock Holmes diagnostic skills, get this book. I plan to keep it close by." (Patricia Wong, Doody´s Book Reviews, November, 2015)

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