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This book introduces the concept of novel process windows, focusing on cost improvements, safety, energy and eco-efficiency throughout each step of the process.
The first part presents the new reactor and process-related technologies, introducing the potential and benefit analysis. The core of the book details scenarios for unusual parameter sets and the new holistic and systemic approach to processing, while the final part analyses the implications for green and cost-efficient processing.
With its practical approach, this is invaluable reading for those working in the pharmaceutical, fine chemicals, fuels and oils industries.

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FROM GREEN CHEMISTRY TO GREEN ENGINEERING - FOSTERED BY NOVEL PROCESS WINDOWS EXPLORED IN MICRO-PROCESS ENGINEERING/FLOW CHEMISTRY
Prelude - Potential for Green Chemistry and Engineering
Green Chemistry
Green Engineering
Micro- and Milli-Process Technologies
Flow Chemistry
Two Missing Links - Cross-Related
NOVEL PROCESS WINDOWS
Transport Identification - The Potential of Reaction Engineering
Chemical Reactivity in Match or Mismatch to Intensified Engineering
Chemical Intensification through Harsh Conditions - Novel Process Windows
Flash Chemistry
Process-Design Intensifiaction
CHEMICAL INTENSIFICATION
Length Scale
Time Scale
Length and Time Scale of Chemical Reactions
Temperature Intensification
Pressure Intensification
MAKING USE OF THE "FORBIDDEN" - EX-REGIME/HIGH SAFETY PROCESSING
Hazardous Reactants and Intermediates
Ex-Regime and Thermal Runaway Processing
EXPLORING NEW PATHS - NEW CHEMICAL TRANSFORMATIONS
Direct Syntheses via One Step
Direct Syntheses via Multicomponent Reactions
Multistep One-Flow Syntheses
Multistep Syntheses in One Microreactor/Chip
Multistep Syntheses in Coupled Microreactors/Chips
ACTIVATE - HIGH-T PROCESSING
Tailored High-T Microreactor Design and Fabrication
Cryogenic to Ambient - Allowing Fast Reactions to be Fast
From Reflux to Superheated - Speeding-Up Reactions
Solvent-Scope Widening by Virtue of Pressurizing Existing High-T Reactions
New Temperature Field for Product and Material Control
Energy Activation Other than Temperature - Photo, Electrochemical, Plasma
PRESS - HIGH-p PROCESSING
Tailored High-p Microreactor Design and Fabrication
High Pressure to Intensify Interfacial Transport in Gas-Liquid Reactions
Pressure as Direct Means - Activation Volume Effects and More
Pressure for Advanced Fluidic Studies - to be Used for Shaping Materials and More
COLLIDE AND SLIDE - HIGH-c AND TAILORED-SOLVENT PROCESSING
Batch Process-Based Inspirations for High-c Flow Processes
Solvent-Free or Solvent-Less Operation - "Highest-c"
Supercritical Fluids to Combine the Former Separated - Mass Transfer Boost
DOING MORE BY COMBINING - PROCESS INTEGRATION
Integration of Reaction and Cooling/Heating, Separation, or Other
Integration of Process Control and Sensing
Thermal Integration on a Process Level
Integration of Units on Racks, Backbones, Frames, Interfaces, or Similar Level
Fully Intensified/Flow Process Development
DOING THE SAME WITH LESS - PROCESS SIMPLIFICATION
Omitting the Use of a Catalyst
Simplifying Separation
IMPLICATIONS OF NPW TO GREEN AND COST EFFICIENT PROCESSING
Introduction
Knowledge-Based Design of Future Chemistry - Coupling the Implementation of NPW with Evaluation and Decision Support Tools
Evaluation Methods
Evaluation of the NPW Concept Impact on Sustainability
Future Environmental and Economic Sustainability Evaluation in the Context of Flow-Chemistry under NPW Conditions
FROM MILLIGRAMS TO KILOGRAMS - SCALE-UP IN MODULAR FLOW REACTORS
Reactor Types
Scale-Up Parameters
Numbering-Up
Single-Channel Operation
Methodology for Continuous-Flow Process Development
Conclusions
EVOLUTION OF NOVEL PROCESS WINDOWS
Multifaceted Novel Process Windows: Evolution
High-p,T Commerical Flow Chemistry Equipment
Funding Agency Initiatives
SCIENTIFIC DISSEMINATION OF NOVEL PROCESS WINDOWS
Literature Share for Chemical Intensification
Literature Share for Process-Design Intensification
OUTLOOK
Process Automation
Means of Activation Other than High-Temperature, High-Pressure, High-Concentration, and High-Solvent
Index

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