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Filip Rázga

Structure and Dynamics of rRNA: A Computational Study

Kink-turn Motif as a Flexible Molecular Hinge
2015. 164 S. 220 mm
Verlag/Jahr: SCHOLAR´S PRESS 2015
ISBN: 3-639-76604-0 (3639766040)
Neue ISBN: 978-3-639-76604-2 (9783639766042)

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In this book, complementary knowledge about the structural and dynamical properties of rRNA secondary motifs (e.g. Kink-turn motifs, GTPase associated center, 16S Helix 44, A-site finger) is presented with prime focus on their intrinsic dynamical properties and related biological functions. The performed molecular dynamics studies provided detailed insight into the structure, dynamics, cation binding, hydration, and molecular interactions of selected rRNA motifs on the nanosecond time scale.
F. Rázga studied biomolecular chemistry at Masaryk University in Brno, and dedicated his PhD work to computational studies of diverse rRNA motifs. Currently, he works as an associate professor at the Polymer Institute of the Slovak Academy of Sciences in Bratislava, with prime research focus on systems providing selective targeting of cancer cells.