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Lead a soft, grey-blue heavy metal found ubiquitously is a common cause of poisoning of domestic animals throughout the world. The propensity for lead to catalyse oxidative reactions and generate reactive oxygen species has been demonstrated in multiple studies. This study was designated to evaluate the protective effect of antioxidants i.e., N-acetyl cysteine (NAC), Lipoic acid (LA) and Glutathione (GSH) in reducing the concentration of lead acetate in blood and soft tissues (liver, kidney, and brain) and their ability to restore altered hematopoietic, hepatic, renal, and other biochemical variables that are indicative of tissue oxidative stress in male rats. It was concluded that NAC and LA provided better protection compared with reduced GSH.

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Dr. Samta Sharma is working as research associates in ICMR project from Jiwaji University. Asha singh is working as research scholar from the same university.Prof Sangeeta Shulkla. D.sc., Ph.d., M.sc. (gold medal in life science) is vice chancellor in Jiwaji University, Gwalior M.P. India. She has published more than 90 research paper.

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