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This book represents an updated review of the physiology of the carotid body chemoreceptors. It contains results in the topics at the frontiers of future developments in O2-sensing in chemoreceptor cells. Additionally, this volume provides data from studies carried out in other O2-sensing tissues including pulmonary vasculature and erythropoietin producing cells. It is a prime source of information and a guideline for arterial chemoreception researchers.

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CONTENTS A Tribute to Professor Autar Singh Paintal: Ravi K. and Vijayan V.K. Structure of Chemoreceptors Immunolocalization of Tandem Pore Domain K+ Channels in the Rat Carotid Body: Yamamoto Y., Taniguchi K. Neuroglobin, a New Oxygen Binding Protein is Present in the Carotid Body and Increases after Chronic Intermittent Hypoxia: Giulio C., Bianchi G., Cacchio M., Artese L., Piccirilli M., Verratti V., Valerio R., Iturriaga R. Hypoxia-Inducible Factor (HIF)-1a and Endothelin-1 Expression in the Rat Carotid Body during Intermittent Hypoxia: Lam S-Y., Tipoe G.L., Liong E.C., Fung M-L. Expression of HIF-2a and HIF-3a in the Rat Carotid Body in Chronic Hypoxia: Lam S-Y., Liong E.C., Tipoe G.L., Fung M-L. Modulation of Gene Expression in Subfamilies of TASK K+ Channels by Chronic Hyperoxia Exposure in Rat Carotid Body: Kim I., Donnelly D.F., Carroll J.L. Postnatal Changes in Gene Expression of Subfamilies of TASK K+ Channels in Rat Carotid Body: Kim I., Kim J.H., Carroll J.L. Morphological Changes in the Rat Carotid Body in Acclimatization and Deacclimatization to Hypoxia: H., Hirakawa H., Oikawa S., Hayashida Y., Kusakabe T. Effect of Carbon Dioxide on the Structure of the Carotid Body: A Comparison between Normoxic and Hypoxic Conditions: Kusakabe T., Hirakawa H., Oikawa S., Matsuda H., Hayashida Y. S-Nitrosoglutathione (SNOG) Accumulates Hypoxia Inducible Factor-1a in Main Pulmonary Artery Endothelial Cells but not in Micro Pulmonary Vessel Endothelial Cells: Fujiuchi S., Yamazaki Y., Fujita Y., Nishigaki Y., Takeda A., Yamamoto Y., Fijikane T., Shimizu T., Osanai S., Takahashi T., Kikuchi K. Changes in Antioxidant Protein SP-22 of Chipmunk Carotid Bodies during the Hibernation Season: K., Wu Y., Nanri H., Ikeda M., Hayashida Y., Yoshizaki K., Ohtomo K. Potential Role of Mitochondria in Hypoxia Sensing by Adrenomedullary Chromaffin Cells: Buttigieg J., Zhang M., Thompson R., Nurse C. Localization of Ca/Calmodulin-Dependent Protein Kinase I in the Carotid Body Chief Cells and the Ganglionic Small Intensely Fluorescent (SIF) Cells of Adult Rats: Hoshi H., Sakagami H., Owada Y., Kondo H. Developmental Aspects of Chemoreceptors Dual Origins of the Mouse Carotid Body Revealed by Targeted Disruption of Hoxa3 and Mash1: Kameda Y. Genetic Regulation of Chemoreceptor Development in DBA/2J and A/J Strains of Mice: Balbir A., Okumura M., Schofield B., Coram J., Tankersley C.G., Fitzgerald R.S., O´Donnell C.P., Shirahata M. Genetic Influence on Carotid Body Structure in DBA/2J and A/J Strains of Mice: Yamaguchi S., Balbir A., Okumura M., Schofield B., Coram J., Tankersley C.G., Fitzgerald R.S., O´Donnell C.P., Shirahata M. The Effect of Hyperoxia on Reactive Oxygen Species (ROS) in Petrosal and Nodose Ganglion Neurons during Development (Using Organotypic Slices): Kwak D.J., Kwak S.D., Gauda E.B. Carotid Body Volume in Three-Weeks-Old Rats Having an Episode of Neonatal Anoxia: Saiki C., Makino M., Matsumoto S. The Effect of Development on the Pattern of A1 and A2a-Adenosine Receptor Gene and Protein Expression in Rat Peripheral Arterial Chemoreceptors: Gauda E.B., Cooper R.Z., Donnelly D.F., Mason A., McLemore G.L. A Comparative Study of the Hypoxic Secretory Response between Neonatal Adrenal Medulla and Adult Carotid Body from the Rat: Rico A.J., Fernandez S.P., Prieto-Lloret J., Gomez-Nino A., Gonzalez C., Rigual R. Molecular Biology of Chemoreceptors In Search of the Acute Oxygen Sensor: Functional Proteomics and Acute Regulation of Large-Conductance, Calcium-Activated Potassium

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