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The 5th edition of this indispensable resource captures the latest insights in neonatal neurology in a totally engaging, readable manner. World authority Dr. Joseph Volpe has completely revised his masterwork from cover to cover, describing everything from the most up-to-the-minute discoveries in genetics through the latest advances in the diagnosis and management of neurologic disorders. He delivers all the clinical guidance you need to provide today´s most effective care for neonates with neurological conditions.

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Unit I: Human Brain Development
Overview

1. Neural Tube Development and Defects

2. Prosencephalic Development and Defects

3. Congenital Hydrocephalus

4. Cerebellar Development and Defects

5. Neuronal Proliferative Events and Defects

6. Neuronal Migrational Events and Defects

7. Organizational Events and Defects

8. Myelination Events and Defects

Unit II: Neurological Evaluation

Overview

9. Neurological Examination: Normal and Abnormal Features

10. Specialized Neurological Studies

11. Neurodevelopmental Followup

Unit III: Neonatal Seizures

Overview

12. Neonatal Seizures

Unit IV: Hypoxic-ischemic and Related Disorders

Overview

13. Pathophysiology General Principles

14. Encephalopathy of the Preterm - Neuropathology

15. Encephalopathy of the Preterm - Pathophysiology

16. Encephalopathy of the Preterm - Clinical - Neurological Features, Diagnosis, Imaging, Prognosis, Therapy

17. Intrauterine, Intrapartum Assessments in the Term Infant

18. Hypoxic Ischemic Injury in the Term Infant - Neuropathology

19. Hypoxic Ischemic Injury in the Term Infant - Pathophysiology

20. Hypoxic Ischemic Injury in the Term Infant - Clinical - Neurological Features, Diagnosis, Imaging, Prognosis, Therapy

21. Stroke in the Newborn

Unit V: Intracranial Hemorrhage

Overview

22. Intracranial/Hemorrhage - Supratentorial (Subdural, Subarachnoid, Intraventricular (Term Infant), Miscellaneous

23. Intracranial Hemorrhage Infratentorial/Cerebellar

24. Preterm IVH/Posthemorrhagic Hydrocephalus

Unit VI: Metabolic Encephalopathies

Overview

25. Glucose

26. Bilirubin

27. Amino acids

28. Organic acids

Unit VII: Degenerative Disorders

29. Degenerative Disorders of the Newborn

Unit VIII: Neuromuscular Disorders

Overview

30. Evaluation, Specialized Studies

31. Arthrogryposis Multiplex Congenita

32. Levels Above Lower Motor Neuron to Neuromuscular Junction

33. Muscle Involvement and Restricted Disorders

Unit IX: Intracranial Infections

Overview

34. Viral, Protozoan and Related Intracranial Infections

35. Bacterial and Fungal Intracranial Infections

Unit X: Perinatal Trauma

36. Injuries of Extracranial, Cranial, Intracranial, Spinal Cord and Peripheral Nervous System Structures

Unit XI: Intracranial Mass Lesions

37. Brain Tumors and Vein of Galen Malformations

Unit XII: Drugs and the Developing Nervous System

Overview

38. Passive Addiction and Teratogenic Effects

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de Vries, Linda S.
Linda de Vries is a neonatologist and pediatric neurologist, and obtained her PhD degree in Utrecht (1987). Since 1989, she has worked in the department of Neonatology in the University Medical Center Utrecht, where she is a professor in Neonatal Neurology. Her research focuses on prediction of neurodevelopmental outcome in high risk preterm and full-term newborns, using neurophysiology and neuro-imaging methods. These at risk children are also seen by her in the follow-up clinic until early childhood. She has a special interest in neonatal stroke and brain plasticity. Her work has been published in 400 publications.

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