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Branchenführende Big-Pharma-Unternehmen und erstklassige Forscher präsentieren grundlegende Konzepte und Herausforderungen bei proteinbasierten Pharmazeutika. Beinhaltet auch eine Einführung in die aus Sicht der Arzneimittelentwicklung fünf wesentlichen Anwendungsbereiche.

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PART 1 - Introduction to Protein therapeutics: past and present
Early recombinant protein therapeutics
Evolution of antibody therapeutics
PART 2 - Antibodies: the ultimate scaffold for protein therapeutics
Human antibody Structure and Function
Antibodies from other species
PART 3 - Discovery and engineering of protein therapeutics
Human antibody discovery platforms
Non-antibody scaffolds and antibody mimetics
Protein engineering: methods and applications
Bispecifics
Antibody-drug conjugates
PART 4 - Physiological and manufacturing considerations for biologics
Pharmacokinetics
Safety Considerations for Biologics
Immunogenicity
Expression Systems for manufacture
Stability, formulation and deliveryPART 5 - Clinical applications
Protein therapeutics in autoimmune and inflammatory diseases
Protein therapeutics in oncology
Protein therapeutics in respiratory diseases
Protein therapeutics in infectious diseases and other indications
Rescue therapies
Biosimilars
PART 6 - Future horizons
Future horizons and new target class opportunities

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